Vectibix® is indicated for the treatment of patients with wild-type RAS (defined as wild-type in both KRAS and NRAS as determined by an FDA-approved test for this use) metastatic colorectal cancer (mCRC):Read More
5.6-month increase in median OS† with Vectibix® + FOLFOX4 vs FOLFOX4 alone in patients with newly diagnosed WT RAS* mCRC1
ASCO Guidelines now strongly recommend anti-EGFR therapy plus doublet chemotherapy 1L for patients with WT RAS* left-sided mCRC3
Join leading clinical experts as they discuss the studies that have helped inform targeted treatment recommendations for patients with WT RAS* mCRC.
FROM PRIME TO PRACTICE
Join Dr. Marwan Fakih as he discusses the importance of moving to more targeted 1L treatment of newly diagnosed WT RAS* mCRC patients.
Dr. Fakih is a paid consultant for Amgen.
Hear clinical experts discuss the real-world implications from the PRIME study.
Dr. Philip and Dr. Tauer are paid consultants for Amgen.
*Defined as wild type in both KRAS and NRAS.1
†Based on total patient counts for patients treated for mCRC from IQVIA longitudinal access and adjudication data (LAAD) claims data from January 2018 through September 2022.6
1L = first-line; ASCO = American Society of Clinical Oncology; ASPECCT = A Study of Panitumumab Efficacy and Safety Compared to Cetuximab; EGFR = epidermal growth factor receptor; FOLFOX = fluorouracil, leucovorin, and oxaliplatin; mCRC = metastatic colorectal cancer; OS = overall survival; PARADIGM = Panitumumab and RAS, Diagnostically-useful Gene Mutation for mCRC; PFS = progression-free survival; PRIME = Panitumumab Randomized Trial in Combination With Chemotherapy for Metastatic Colorectal Cancer to Determine Efficacy; WT = wild type.
Dr. Fakih is a paid consultant for Amgen.
REAL-WORLD TREATMENT IMPLICATIONS
FROM THE PRIME STUDY
Drs. PHILIP AND TAUER
Drs. Philip and Tauer
Dermatologic Toxicity: Dermatologic toxicities occurred in 90% of patients and were severe (NCI-CTC grade 3 and higher) in 15% of patients receiving Vectibix® monotherapy [see Dosage and Administration (2.3), Warnings and Precautions (5.1), and Adverse Reactions (6.1)].
Please see Vectibix® full Prescribing Information, including Boxed WARNING.
Vectibix® is indicated for the treatment of patients with wild-type RAS (defined as wild-type in both KRAS and NRAS as determined by an FDA-approved test for this use) metastatic colorectal cancer (mCRC):
Vectibix® is not indicated for the treatment of patients with RAS-mutant mCRC or for whom RAS mutation status is unknown.
Dermatologic Toxicity: Dermatologic toxicities occurred in 90% of patients and were severe (NCI-CTC grade 3 and higher) in 15% of patients receiving Vectibix® monotherapy [see Dosage and Administration (2.3), Warnings and Precautions (5.1), and Adverse Reactions (6.1)].
References 1. Vectibix® (panitumumab) prescribing information, Amgen. 2. Douillard J-Y, Oliner KS, Siena S, et al. N Engl J Med. 2013;396:1023-1034. 3. Watanabe J, Muro K, Shitara K, et al. JAMA. 2023;329:1271-1282. 4. Yamazaki K, Muro K, Watanabe J, et al. Presented at: American Society of Clinical Oncology (ASCO) Annual Meeting; June 2-6, 2023; Chicago. 5. Morris VK, Kennedy EB, Baxter NN, et al. J Clin Oncol. 2023;41:678-700. 6. Data on file, Amgen; 2022.